INDICATORS OF MANOMETRY AND pH-IMPEDANSOMETRY IN THE MANAGEMENT OF PATIENTS WITH REFRACTORY GASTROESOPHAGEAL REFLUX DISEASE
Keywords:
gastroesophageal reflux disease, proton pump inhibitors, refractoriness, pH-impedancemetry, high resolution manometry.Abstract
Gastroesophageal reflux disease (GERD) is a widespread disease that has a significant impact on the quality of life of patients and is a leading risk factor for the development of esophageal adenocarcinoma. Currently, proton pump inhibitor therapy (PPI) is the basic treatment for patients with GERD, but 1/3 of patients show resistance to the prescribed therapy.
Currently, 24-hour pH-impedancemetry and high-resolution esophageal manometry are the most informative diagnostic methods in patients resistant to PPI therapy. These methods allow timely recognition of the causes of the refractory course of GERD, differential diagnosis with other nosologies, timely correctionadminister therapy individually for each patient.
References
Abu Ali ibn Sina (Avicenna). Canon of Medicine. Ed. ENIO; 2003.
Rossetti M. The reflux disease of the esophagus--clinical-surgicalaspects. Hippokrates. 1967;38(3):92-97.
Dent J, Brun J, Fendrick M, Fennerty J, Janssens P, Kahrilas K, Lauritsen J, Reynolds M, Shaw N. Talley on behalf of the Genval Workshop Group An evidence-based appraisal of reflux disease management-the Genval Workshop Report. Gut 1999;44(suppl2):S1-S16.doi:10.1136/gut.44.2008.S1
Vakil N, Zanten S, Kahrilas P, Dent J, Jones R. Global Consensus Group The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gas-troenterol.2006;101(8):1900-1920. doi: 10.1111/j.1442-2050.2011.01271.x
Ivashkin V.T., Maev I.V., Trukhmanov A.S., Baranskaya E.K., Dronova O.B., Zairatyants O.V., Pasechnikov V.D., Saifutdinov R.G., Sheptulin A.A., Kucheryavy Yu.A., Lapina T.L., Storonova O.A., Kaibysheva V.O. Gastroesophageal reflux disease. Clinical guidelines. Moscow, 2014.
Ivashkin V.T., Maev I.V., Trukhmanov A.S. Barret's esophagus. In two volumes. M.: Publishing house "Shiko"; 2011.
Dent J. Endoscopic grading of reflux oesophagitis: the past, present and future. Best Pract Res Clin Gastroenterol. 2008;22(4):585-599.doi:10.1016/j.bpg.2008.01.002
th United Europeangastroenterology week. Birmingham, United Kingdom, 18-23 October 1997. Abstracts. gut. 1997;41(Suppl 3):A1-258,E1-61.
El-Serag H, Sweet S, Winchester C, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review.gut2014;63:871-880.doi:10.1136/gutjnl-2012-304269
Khodjieva GS Pharmacoeconomics and the patients' compliance as an essential part of successful therapy of iron deficiency anemia. //Indonesian Journal of Innovation Studies-Vol. 18 (2022): April 2022–2-7p.
Khodjiyeva GS Pharmacoeconomics and the patients compliance as an essential part of therapy of iron deficiency anemia // Uzbek medical journal. - 2020. - Volume 6, Issue 1. - P. 37-43.
Khodjiyeva GS Pharmacoeconomics and the patients compliance as an essential part of successful therapy of iron deficiency anemia // Evropean journal of molecular and clinical medicine. - 2020. - Volume 7, Issue 11. - P. 2550-2554.
