Features of pH-Impedancemetry and Manometry Indicators in the Management of Patients with Refractory Gastroesophageal Reflux Disease

Abstract

Gastroesophageal reflux disease (GERD) is a widespread disease that has a significant impact on the quality of life of patients and is a leading risk factor for the development of esophageal adenocarcinoma. Currently, proton pump inhibitor therapy (PPI) is the basic treatment for patients with GERD, but 1/3 of patients show resistance to the prescribed therapy.