Metastatic Lung Disease Parables, The Oncologist's View
Keywords:
Lung cancer, AngiogenesisAbstract
Metastasis in lung cancer is a multifaceted process. In this review, we will dissect the process in several isolated steps such as angiogenesis, hypoxia, circulation, and establishment of a metastatic focus. In reality, several of these processes overlap and occur even simultaneously, but such a presentation would be unreadable. Metastasis requires cell migration toward higher oxygen tension, which is based on changing the structure of the cell (epithelial-mesenchymal transition), orientation within the stroma and stroma interaction, and communication with the immune system to avoid attack. Once in the blood stream, cells have to survive trapping by the coagulation system, to survive shear stress in small blood vessels, and to find the right location for extravasation. Once outside in the metastatic locus, tumor cells have to learn the communication with the “foreign” stroma cells to establish vascular supply and again express molecules, which induce immune tolerance.
References
Mamedov U. S., Pulatova D. SH. The Results of Cancer Treatment of the Oral Caviti Tumors in //the Republic of Uzbekistan European journal of Pharmaceutical and Medical Research.-2019.-6 (9).-P. – С. 326-329.
Mamedov U. S., Khodjaeva D. I. Modern diagnostic approachкеtreatment of thyroid cancer //International Journal of Development and Public Policy. – 2021. – Т. 1. – №. 4. – С. 101-105.
Мамедов У. С., Нуров Ж. Р. Результаты комбинированных и комплексных методов лечения рака глотки //Вестник науки и образования. – 2020. – №. 24-3 (102). – С. 68-74.
Мамедов У. С. К вопросу о лечении регионарных метастазов опухолей орофаренгиальной зоны //Бюллетень ассоциации врачей Узбекистана. – 2011. – №. 3. – С. 61-63.
Sunnatovich M. U., Kizi A. M. A. Radiation Diagnostics of Liver Echinococcosis //Central Asian Journal of Medical and Natural Science. – 2021. – Т. 2. – №. 5. – С. 424-433.
MAMEDOV U. S. Improvement of Extended Lymphadenectomy in the Treatment of Tumors of the Oropharyngeal Region //" ONLINE-CONFERENCES" PLATFORM. – 2021. – С. 125-125.
Мамедов У. С., Нарзиева Д. Ф. Отдаленные результаты лечения рака слизистой полости рта //Вестник науки и образования. – 2020. – №. 24-3 (102). – С. 75-81.
Мамедов У. С. ОТДАЛЕННЫЕ РЕЗУЛЬТАТЫ ЛЕЧЕНИЯ РАКА СЛИЗИСТОЙ ПОЛОСТИ РТА //Журнал теоретической и клинической медицины. – 2015. – №. 3. – С. 115-119.
Мамедов У. С. и др. ОЦЕНКА ЛУЧЕВЫХ МЕТОДОВ ДИАГНОСТИКИ АСЕПТИЧЕСКОГО НЕКРОЗА ТАЗОВОГО СУСТАВА //Наука и технология в современном мире. – 2023. – Т. 2. – №. 12. – С. 12-13.
Мамедов У. С., Темирова Д. В. ОЦЕНКА ПОСЛЕОПЕРАЦИОННЫХ ИСХОДОВ У ПОЖИЛЫХ ЖЕНЩИН С РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ //Наука и технология в современном мире. – 2023. – Т. 2. – №. 9. – С. 73-74.
Мамедов У. С. ЛЕЧЕНИЕ ОПУХОЛЕЙ ОРОФАРЕНГИАЛЬНОЙ ОБЛАСТИ, ОСЛОЖНЕНИЯ ВЫЗВАННЫЕ ЛУЧЕВОЙ ТЕРАПИЕЙ (ОБЗОР) //BARQARORLIK VA YETAKCHI TADQIQOTLAR ONLAYN ILMIY JURNALI. – 2023. – Т. 3. – №. 1. – С. 286-290.
Ilkhomovna K. D. Morphological Features of Tumor in Different Treatment Options for Patients with Locally Advanced Breast Cancer //International Journal of Innovative Analyses and Emerging Technology. – 2021. – Т. 1. – №. 2. – С. 4-5.
Khodzhaeva D. I. Changes in the Vertebral Column and Thoracic Spinecells after Postponement of Mastoectomy //International Journal of Innovative Analyses and Emerging Technology. – 2021. – Т. 1. – №. 4. – С. 109-113.
Khodjayeva D. I. MORPHOLOGY OF IDIOPATHIC SCOLIOSIS BASED ON SEGMENT BY SEGMENT ASSESSMENT OF SPINAL COLUMN DEFORMITY //Scientific progress. – 2022. – Т. 3. – №. 1. – С. 208-215.
Ilkhomovna K. D. Modern Look of Facial Skin Cancer //BARQARORLIK VA YETAKCHI TADQIQOTLAR ONLAYN ILMIY JURNALI. – 2021. – Т. 1. – №. 1. – С. 85-89.
