FIBROTIC CHANGES IN THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS AFTER SUFFERING COVID-19

Abstract

In February 2020, a pandemic of a viral infection caused by the new coronavirus SARS-CoV-2 was declared in the treasure trove of factors of the immune system and genetic predisposition. The number of people who have had a new coronavirus infection is steadily increasing worldwide. Comparison of data on its pathogenesis, clinical course, complications and outcomes with other respiratory viral infections, primarily caused by Betacoronavirus pathogens of the same kindBetacoronavirus, gives reason to expect an increase in the number of patients after COVID-19 with delayed lesions of the cardiovascular, respiratory and other systems in the near future. In the pathogenesis of possible complications, the leading role will belong to disorders of the functioning of the immune system, primarily the adaptive immune response. This review examines the involvement of subpopulations of T-helper cells and humoral factors produced by them in the pathogenesis of complications of viral (coronavirus) infections involving the cardiovascular and respiratory systems, as well as known data on the genetic determination of cytokine-producing activity of these cells.