ОНА СУТИ ГОРМОНЛАРИ ВА ЯНГИ ТУҒИЛГАН АВЛОДНИНГ ЛАКТАЦИЯ ДАВРИДАГИ ИММУНИТЕТИ
Keywords:
она сути, каламуш, иммуноглобулинлар, адипонектин, лептинAbstract
Одамнинг она сутида иммуннологик фаоллIgи бўлган биологик фаол омилларнинг таркиби кенг ўрганилган. Бироқ, лактатсия даврининг дингамикасида каламуш сутининг иммунитет омиллари ҳақида маълумот етарли эмас. ҳали ҳам яхши тушунилмаган. Ушбу мақолада каламуш она сутидаги иммуноглобулин (Ig) таркиби ва лактация даврида бир нечта муҳим адипокинлар ва ўсиш омилларини таҳлил қилиниб, тегишли плазма даражалари билан муносабатлари баҳоланган. Лактация даврида трансформацияловчи ўсиш омили (TGF)-β2 ва TGF-β3 нинг сут концентрацияси биринчи ҳафтада бир даражага кўтарилиши, адипонектин ва лептин эса барқарор бўлиб қолиши кўрсатилаган. Лактатсиянинг иккинчи даврида (14-21 кун), сут эпидермал ўсиш омили (ЕGF) ўсишига қарамасдан, 21-куни фибробласт ўсиш омили 21 (FGF21) камайиши кўрсатилган. Лактация даврида сут IgА концентрацияси аста-секин ўсиб бориши, аммо сезиларли ўзгаришлар кузатилмаганлIgи таъкидланган. Аниқланган IgМ ва IgG-да топилган. Плазма даражасига келсак, иккинчи лактация даврида ўрганилган барча адипокинларда пасайиш кузатилди, IgА ва TGF-1 бундан мустасно, тадқиқот охирида максимал қийматга эришди. IgМ, IgG ва адипокин концентрацияси ўртасида ижобий корреляция аниқланди, сут ва плазма бўлинмалари орасида топилган. Хулоса қилиб айтишимиз мумкинки, ушбу тузилмалардаги ўзгаришлар каламушларнинг сути ва плазмасидаги биологик фаол бирикмалар ва уларнинг лактация давридаги муносабатларини аниқлайди.
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